The Clinical Information System (Clinical IS) of PrognoChip manages the Electronic Health Record (EHR) of breast cancer patients, by storing information related to patient identification and demographic information, medical history (past diseases, surgeries, medications, gynecological history), patient risk factors, family history of malignancy, clinical examinations and findings, results of laboratory exams (mammography, ultrasound, hematological and biochemical exams, etc.), histopathologic evaluation and TNM staging (indicating Tumor size, Lymph node involvement, and Metastatic spread), pre-surgical and post-surgical therapies, as well as therapy effectiveness and follow-up exams. The Clinical IS is actually the extension with breast cancer concepts of a patient-oriented Integrated Health Care Environment, called Integrated Care Solutions, developed by the Biomedical Informatics Lab of FORTH-ICS. The system is based on a client-server achitecture, runs on a PC Server, and uses an SQL Server database backend. For the needs of PrognoChip, the Clinical IS has been installed at PAGNH and PROLIPSIS.