Lecture
Clustering of 3D (gene-condition-time) gene expression datasets
Speaker: |
Jochen Supper |
Date: |
Monday, 2 July 2007 |
Time: |
11:30-12:30 |
Location: |
Right seminar room, 2nd floor Building C, FORTH. Heraklion, Crete |
Host: |
Martin Reczko |
Abstract: |
Cells co-regulate the expression
of genes forming modules to respond to environmental stimuli.
Depending on the stimulus, these modules contain different genes,
have distinct temporal response patterns or are left unaffected.
Today, an increasing pool of microarray datasets monitoring gene
expression over time exists. These gene-time datasets can be searched
for coregulated gene expression modules by one of the many clustering
methods published so far. However, for an integrative analysis, several gene-time datasets can be joined into one three-dimensional gene-condition-time dataset, to which standard clustering or biclustering methods, however, cannot be applied. In this work we present a novel probabilistic clustering approach for gene-condition-time datasets. |
Bio: |
Jochen Supper is a research
assistant at the Centre for Bioinformatics (ZBIT), University
of Tu"bingen. He is interested in deciphering regulatory signals
controlling gene expression, analyzing the robustness of Signaling
pathways, cluster multi-conditioned microarray datasets and immunoinformatics. For more information please have a look at his web site: http://www-ra.informatik.uni-tuebingen.de/mitarb/supper/welcome_e.html |