Lecture
MicroRevolution: Computational/experimental analysis
of microRNA biogenesis and function
Speaker: |
Artemis G. Hatzigeorgiou |
Date: |
Thursday, 24 May 2007 |
Time: |
11:00-12:00 |
Location: |
"Mediterranean Studies" Seminar Room, FORTH. Heraklion, Crete |
Host: |
Dr. Martin Reczko |
Abstract: |
MicroRNAs (miRNAs) are ~22
nucleotide non-coding RNA, which regulate expression of protein-coding
genes through translation repression and/or degradation of mRNA.
They are known to regulate cell proliferation and death and it
has been found that miRNA expression signatures can distinguish
cancer subtypes or predict biological and clinical behavior within
the same cancer type. The understanding of miRNA function is likely
to lead to novel therapeutically treatment of cancer. Combined
computational/experimental approaches have played a significant
role during recent years in the identification of novel microRNAs
(miRNAs), as well as in the analysis of their function. We have
developed several tools for analyzing the genomic organization
and function of miRNAs ( DIANA-microT, TarBase, and miRGen) and
a microRNA gene finder. Recently we have supported research on
edited miRNAs in brain and investigated the role of SNPs within
miRNA targets. |
Bio: |
Penn Center for Bioinformatics,
School of Medicine, University of Pennsylvania, Philadelphia. |